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Would it be a good practice to install minimal Debian and learn to use Nix package manager with it?
Literally just what you said, it’s that easy. The only question is whether you want to use any debian DE at all or not.
Debian has extraordinarily sane and basic defaults, whether you need it as a base for vms, lxc containers, nix and other overlays, or whatever.
If you want a system specifically to use the Nix package manager, just use NixOS.
